Specialties
drug delivery technologies, pharmaceutical products, product development services, and contract manufacturing
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Top Pharma Contract Manufacturers in Australia
Pharma Trends
Top Pharma Contract Manufacturers From EU
Specialties
Contract Development & Manufacturing Organization (CDMO), Highly Potent APIs, Formulations, Drug Products, Peptides, Lipids, Carbohydrates, Injectables, Small Molecule APIs & Excipients, Antiobiotic & Oncology APIs & Drug Products, and Primary & Secondary Packaging
Specialties
pharmaceuticals, formulation, preformulation, analytical development, manufacturing, logistics, clinical trial supplies, and QP service
Specialties
Nuclear Medicine, PET Imaging, Molecular Imaging, cGMP Manufacturing , Contract Manufacturing, and SPECT Imaging
contract development and manufacturing organisation (CDMO) for both APIs and finished dose forms
Specialties
Sterile production, Chemical, High potency, and Contract Manufacturing
Chemo :Specialties
Active pharmaceutical ingredientes (APIs), Finished dosage forms (FDFs), Women`s Health, Respiratory Health, Cardiovascular, Animal Health, Biopharmaceuticals, Branded pharmaceuticals, Gastroenterology, Endocrinology, Dermatology, and Major therapeutic areas
development and production of active therapeutic substances (mainly beta-lactam active ingredients), and the development and manufacture on contract of products and intermediates obtained from fermentation processes for third parties in the food, cosmetic and biotechnology industries.
Specialties
R&D Projects, Pharma Marketing, Contract Manufacturing, Licensing, Contract Development, Microspheres, Liposomes, Oncology, and Urology
Specialties
API & Intermediates manufacturing under cGMP, High value chiral materials, Amino acid & peptide chemistry on large scale, 100% self-owned & operated Facilitiy in China, Process R&D, cGMP manufacturing, RSMs, Family owned & run since 1950, CDMO, CMO, API, Expereinced, Process Chemistry, cGMP, and Custom API development
leading European manufacturers of Bulk Active Pharmaceutical Ingredients having a portfolio of more than 50 products, with Drug Master Files lodged worldwide. Dipharma serves top ranking pharmaceutical companies in Europe, U.S.A. and Japan.
Specialties
Pharmaceutical Manufacturing, Medical Device Manufacturing, and Nutraceutical Manufacturing
Olon is an Italian company world leader in the Active Pharmaceutical Ingredients (APIs) production, using synthetic and biological processes for Generic market as well as in Contract Development and Manufacturing (CDMO)
Specialties
Pharmaceuticals third party manufacturing, Special Services, and Super Generics
Specialties
Contract Manufacturing, Private Label, Medical Devices, Food Supplements, and Dermocosmetics
Specialties
Analytical Services, Solid State Development (Polymorphism, Salts and Crystallization), Pharmaceutical Development, Catalysis Technology, Biopharmaceutical Analysis, API Manufacturing, Biological Analysis, Custom Synthesis, Small Molecules Analysis, Ligands, Extractables & Leachables, Quality Control, and Troubleshooting
Top Pharma Contract Manufacturers Based Out Of US and Neighbouring Regions : 7th
Specialties
Contract Manufacturing, Contract Packaging, Contract Molding/Medical Device, and Technology Transfer
Specialties
• Biologics • Medical Device • NaturalProducts • Personal Care • Pet Cosmetics • Pharmaceutical
Specialties
Contract manufacturing and Contract clinical research
Specialties
Contract Development and Manufacturing, Drug Substance (API) Development and Manufacturing, Drug Product Development and Manufacturing, and Analytical Development, Validation and Testing
Specialties
Contract Development and Manufacturing, Formulation Development, Antibody Drug Conjugation, Off Patent APIs, HPAPI, ADC, Oral Solids, and Sterile Injectibles
Specialties
Contract Pharmaceutical Packaging, Repackaging, Manufacturing, Pharmaceutical Serialization, Track and Trace, and Pharmaceutical Labels
Specialties
Topical Product Development, Analytical Testing Laboratory, In Vitro Release Testing, Contract Research Organization, Product Testing Laboratory, Skin Permeation, Pharmaceutical Testing Services, Dermatology Product Development, and GMP manufacturing
Specialties
Analytical Methods Development & Validation, Formulation Development, Fast-Track FTIM Studies, Clinical Trial & Commercial Manufacturing, Controlled Release Drug Delivery, Potent Products, and Bioavailability Enhancement
Specialties
Formulation Development, Clinical Supply Manufacturing, Pharmaceuticals, Solid Oral Dosage Forms, Tablets, Manufacturing, Phase I and II Clinical Supplies, Analytical Formulation, Release & Stability, Small Pharma, Capsules, Granules, Proof, Concept, and Proof of concept
Specialties
Sterile liquid and powder filling, cGMP API and solid dose production, medicinal chemistry, dosage form development, integrated drug development & mfr, process development, analytical development, ICH stability testing, custom drug conjugation, chemical synthesis, Reference Standards, and Research Molecules
Specialties
Contract Manufacturing and Allergy Testing & Treatment Supplies
Specialties
Sterile Filling Opthalmic/Otic/Nasal, FDA and Health Canada Successful Audits, Packaging, Tablets, Capsules, and Coating
Top Pharma Contract Manufacturers From India
Specialties
Finished Formulations, Pre-Clinical/Clinical Trials, Bulg Drugs/API, Agro products, Discovery Research Services, Pharma Machinery, and Contract Manufacturing
Specialties
APIs, Advance Intermediates, Fine Ingredients, Drug Discovery Solutions, Nutritional Products, Life Sciences Chemicals, Solid Dosage Forms, Radiopharmaceuticals, Allergy Therapy Products, Crop Science Chemicals, and CMO of Sterile Injectables
Specialties
Opthalmic products, Nasal products, Respiratory Care, lnjectibles, Marketing & Distribution through Strategic Partners, Contract Manufacturing, and Sales & Marketing
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CONTRACT RESEARCH, CUSTOM SYNTHESIS, APIs in US FDA Facility, and API INTERMEDIATES
Specialties
Apomorphine, Buprenorphine, Ispaghula Husk, Eflornithine, Fentanyl, Methadone, and Nalbuphine, Nalmefene, Naloxone, Naltrexone, Promedol, Tramadol, etc.
Specialties
API Manufacturing, Product and Process Development, Intermediate Manufacturing, Analytical Method Development, Contract Manufacturing, Stability Studies, Drug Master File/CMC Preparation, and Process Optimization
Specialties
APIs, Advanced Intermediates, Central Nervous System, Urinary Incontinence, Cardiology, Anthelmintic, Alzheimer’s, Schizophrenia, Depression, Diabetes, CRAMS, and NCE
Specialties
Pharmaceuticals, Suppositories and pessaries, Anti-malarials, Contract Research and Manufacturing Services, Healthcare products, Lozenges, Herbal Lozenges, Oral Tablets, and Effervescent tablets
Top Excipient Suppliers In Pharma Sector
Specialties
Film Coating, Enteric Coating, Controlled Release Polymers, Excipients for tablets and capsules, Multiparticulate Dosage Forms, Taste-Masking, Oral Dosage Formulation, and Tablet Design :Region – US
Specialties
Lactose Monohydrate, Anhydrous Lactose, Co-processed Excipients, Lactose for Inhalation, Tailor-made lactose products, Spray drying, Co-processing, Agglomeration, and Product Customization : Region – Germany
Specialties
Manufacturing Pharma Ready Mix Film Coating Material (NOVOMIX) and Manufacturing Unique range of Directly Compressible Excipients (NOVOPOWER
Specialties
Hard Gelatin Capsules, HPMC vegetable capsule, Pullulan vegetable capsules, Empty capsules, and Pharmaceutical Excipients : China
Specialties
USP/NF Excipients, Active Pharmaceuatical Ingredients, USP Dietary Supplement Ingredients, USP Cosmetic Ingredients, USP/FCC Food Ingredients, and Research Organic : US
Specialties
Oral Dispersible Tablets (ODT), Oral Dispersible Powder (ODP), Antacid Actives, Excipients, Drug Development Services, Taste-Masking, Vaccine Adjuvants, Drug Delivery Systems, and Plasticizers for Soft Gel Capsules : US
Specialties
Broadest array of excipients in the marketplace, Most complete portfolio of high functionality excipients, Technical expertise for the global pharmaceutical and nutritional industries, and Excellent quality and customer service systems : US
Specialties
Lipid chemistry, Plant extraction, Pharmaceuticals, Personal care, Formulation, Lipid excipients, and Cosmetic ingredients
Specialties
Pharmaceutical Excipients, Active Pharmaceutical Ingredients, Omega-3 Fatty Acids, Solubilization, Skin Delivery, Biologic Solutions, Instant & Modified Release, Softgels, and Regulatory Support
Specialties
Contract Development & Manufacturing Organization (CDMO), Highly Potent APIs, Formulations, Drug Products, Peptides, Lipids, Carbohydrates, Injectables, Small Molecule APIs & Excipients, Antiobiotic & Oncology APIs & Drug Products, and Primary & Secondary Packaging
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Top API contract manufacturers in Mexico
About Companies
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Megafine, established in 1995, is a privately owned and professionally managed enterprise with it’s corporate office in Mumbai and two multipurpose manufacturing sites at Vapi & Nashik in India, Vapi facility being successfully inspected by US-FDA and the Nashik facility is being approved by BGVFHH Germany (EMA EU-GMP), Japan PMDA, Health Canada, TGA Australia, COFEPRIS Mexico & Korea MFDS. Both the plants are also certified by WHO GMP, ISO 9001:2008, 14001:2004 & OHSAS 18001:2007 and have been audited by several Innovators and leading Generic companies from time to time.
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Uquifa is the API division of Vivimed Labs. Uquifa is a manufacturer of Active Pharmaceutical Ingredients (APIs) and intermediates for the pharmaceutical Industry. Operates 3 manufacturing sites, 2 in Spain and 1 in Mexico, which operates under cGMP conditions and has been inspected and approved by major Pharmaceutical Companies and Regulatory Authorities, including the US FDA. Uquifa sells to more than 70 countries worldwide and has more than 150 active DMF´s filed and 26 COS approved. Uquifa counts amongst its customers the major Generic and Ethical companies operating in the Industry and continues to invest in personnel and facilities to maintain a strong technology offering to both, the Generic Industry and the Ethical Pharmaceutical Industry. In addition to our stable generic portfolio, UQUIFA works as CMO, developing and producing Toll Manufacture and Custom Synthesis giving assistant to your business. Fulfilling regulatory and quality requirements to ensure your product is produced in in the same way as if you perform internally.
Top API Contract Manufacturers with presence/ from China
- Frontage Laboratories
- Flamma
- Medichem
- Hansyn Pharma
- LGM Pharma
- Shenzhen Zhijun Pharma
- Onyx
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Everything you need to know about ranking of global API suppliers
API Contract Manufacturing
API, active pharmaceutical ingredient is key spend line item for pharmaceutical companies. In order to have strategic alliance with right vendor, one should evaluate API manufacturing experience that each vendor carries. Best way to check API mfg strength of potential strategic vendors is by evaluating their US DMF count. Below is the list of top 10 US DMF holders in Type II category.
Type II Drug Substance, Drug Substance Intermediate, and Material Used in Their Preparation, or Drug Product
| Company | US DMF Count |
| TEVA or TAPI | 311 ( website says 370 APIs ) |
| MSN | 266 ( website says 152 APIs ) |
| AUROBINDO PHARMA | 215 (SEC filings states 220 APIs) |
| MYLAN | 213 ( website says 250 APIs ) |
| DR REDDY | 205 ( website says 450 + globally) |
| HETERO DRUGS | 202 |
| LUPIN | 182 |
| SUN PHARMA | 160 |
| CIPLA | 156 |
| CADILA | 137 |
As expected, market was led by TAPI which holds close to 311 DMFs under Type II DMF category, followed by MSN, Aurobindo, Mylan & Dr Reddy.
Below are some important points from analysis:
- Total of 10243 active DMF count were recorded in Type II DMF category.
- Top 12 players accounted for ~23% of overall DMF count, with more than quarter of this 23% coming from Teva and MSN alone.
- Only 5 companies accounted for greater than 2% of DMF count share, and included likes of Dr Reddy, Aurobindo Pharma, Mylan and two mentioned in above point.
DMF count might appear as just another number but it is one of the most important KPI to understand vendor’s technical know-how. Hence, the above mentioned vendors if part of your incumbent list, should be retained as is, and must be transitioned to strategic vendors going forward. If otherwise, these suppliers must be positioned in your preferred partner list, probably for future consignments mapped to large volumes.
Source 1 : http://www.msnlabs.com/api-dmfs.html
Source 2 : http://www.aurobindo.com/docs/press-room/press-reports/aurobindo-pharma-ltd-q4-fy-16-17-and-fy-1617-press-release.pdf
Source 3 : https://www.tapi.com/ProductCatalog.pdf?v=812
Source 5 :http://www.drreddys-cps.com/apis-and-intermediates/commercial-supplies/
AbbVie and Calico, and we shall say no more
AbbVie and Calico bolster their partnership in quest to solve age linked health challenges
Two best innovators join hand to deal with age related health issues. With close to 24 early stage developments – which are on their way to commercialisation, the duo are likely to change the face of healthcare in coming days. Below is news release from Calico’s website:
https://www.calicolabs.com/news/2018/06/26/
– Extension builds on collaboration established in 2014
– Collaboration focuses on aging and age-related diseases, including neurodegeneration and cancer
AbbVie (NYSE: ABBV), a research-based global biopharmaceutical company, and Calico, a company focused on aging research and therapeutics, today announced an extension of their collaboration to discover, develop and bring to market new therapies for patients with age-related diseases, including neurodegeneration and cancer.
Calico is the Alphabet-backed life sciences company that is led by former Genentech chairman and CEO Arthur D. Levinson, Ph.D. With more than 150 employees, Calico has established a world-class research and development facility in the San Francisco Bay Area.
Working together with AbbVie, Calico pursues discovery-stage research and development. AbbVie provides scientific and clinical development support and will lend its commercial expertise to lead future development and commercialization activities. Since 2014, the collaboration between the two companies has produced more than two dozen early-stage programs addressing disease states across oncology and neuroscience and yielded new insights into the biology of aging.
“We’ve built a successful collaboration – both scientifically and culturally – that is advancing cutting-edge science,” said Michael Severino, M.D., executive vice president, research and development, chief scientific officer, AbbVie. “Calico has attracted an outstanding team of world-class scientists and the extension of this collaboration allows us to further build on the research we’ve done to identify transformative treatment options for patients with age-related diseases.”
“Our collaboration with AbbVie has fully met our high expectations,” said Dr. Levinson. “Our initial agreement created a unique partnership and this extension will accelerate further our efforts to understand the science of aging to advance novel therapies for patients.”
Under the terms of the agreement, the collaboration between the two companies is now extended for an additional three years. Calico will be responsible for research and early development until 2022 and will advance collaboration projects through Phase 2a through 2027. AbbVie will continue to support Calico in its early R&D efforts and, following completion of Phase 2a studies, will have the option to manage late-stage development and commercial activities. Both parties will share costs and profits equally. AbbVie and Calico will each commit to contribute an additional $500 million to the collaboration.
Thermo Fisher Scientific : Where precision is not just word but a mission
Thermo Fisher Scientific Inc., one of the world’s top life science company opens it U.S. Precision Medicine Science Center (PMSC) in Cambridge, Mass.
This facility beholds technologies that addresses collaborators need of analytical workflows which can generate precise molecular profiles of patients. This data will ultimately complement collaborators quest to treat disease effectively in clinical set-ups.
The centre also houses best in class experts who can help current and potential clients expedite journey from biomarker discovery to assay development. Company intends to achieve this by compressing R&D timelines.
Company Quotes
“For health and science innovators, a bottleneck exists today between the discovery of biomarkers and their widespread use at the point of care,” said Emily Chen, senior director, Thermo Fisher Precision Medicine Science Center. “Our goal at the PMSC is to remove that bottleneck and help scientists and physicians reduce the time it takes to demonstrate clinic validity and utility.”
“Precision medicine needs to be based on high-quality data, and proteomics is central to that,” said PMSC collaborator Jennifer Van Eyk, PhD, Cedars-Sinai Medical Center in Los Angeles. “Our work with the team at the PMSC is helping us accelerate the important journey from discovery to patient care.”
This is not first time that company has opened PMSC centre, Thermofisher in past has opened similar centre in China that looks to address same challenges.
This 20 billion dollar sales company has unique blend of services that range from life science research to patient diagnostics, stretching far beyond to laboratory offerings. It is this combination that has positioned the company to forefront of innovation, which is well reflected in its global strategic decisions. For more updates on Thermo fisher and its peers, follow Pharmed Intel.
